![]() EES (including expend EES) allows tumor removal at anterior skull base, parasellar, suprasellar, and petroclival regions from the midline access. Although with the recent development of neuroendoscopic equipment, intraoperative hemostatic materials, and the concept of skull base reconstruction, EES has been employed in various types of skull base tumors. Multivariate analysis revealed that the suprasellar lesion, subarachnoid invasion, and intraoperative grade 3 flow CSF leakage were the risk factors of CSF leakage after operation, while the bone flap was a protective factor.Ĭonclusion: Bone flap combined with VP-NSF and iodoform gauze for skull base reconstruction is recommended in high-risk patients, while postoperative lumbar cistern drain remains dispensable.Ĭerebrospinal fluid (CSF) leakage is a pathologic condition where CSF flows out from defects of the dural and skull base, and it can be caused by a multitude of different factors, mainly including trauma ( 1) and endoscopic endonasal surgery (EES). Excluding one case who died of severe intracranial infection, the rest were cured and discharged without obvious sequelae. During the repair surgery, insufficient embedded fat was detected in one case detected, seven with breached inner artificial dura, three had vascularized pedicle nasoseptal flap (VP-NSF) displacement, two with VP-NSF perforation, two with VP-NSF inactivation, and one with imperfect adherence to VP-NSF to the skull base. Among these 12 cases, 3 were repaired twice, and the rest were cured the first time. Results: Postoperative CSF leakage occurred in 14 patients (3.9%), 2 of them cured by lumbar cistern drainage, 12 underwent endoscopic repair. The associations between postoperative CSF leakage and patient demographics, medical history, tumor characteristics, and intraoperative repair techniques were analyzed the diagnosis and repair of postoperative CSF leakage were also introduced. Methods: A retrospective review of 360 patients who underwent EES was included. ![]() This study aims to identify potential risk factors of postoperative CSF leakage. Objective: Postoperative cerebrospinal fluid (CSF) leakage following endoscopic endonasal surgery (EES) is a frequent complication. 2Operating Theater, The First Affiliated Hospital of Nanchang University, Nanchang, China. ![]() 1Department of Neurosurgery, The First Affiliated Hospital of Nanchang University, Nanchang, China. ![]() Yicheng Xiong 1,†, Yajing Liu 2,†, Guo Xin 1, Shenhao Xie 1, Hai Luo 1, Liming Xiao 1, Xiao Wu 1, Tao Hong 1 and Bin Tang 1* ![]()
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